微生物合成聚羟基脂肪酸酯MICROBIAL SYNTHESIS OF POLYHYDROXYALKANOATES
徐军,贺文楠,张增民,陈国强
摘要(Abstract)：
微生物合成的聚羟基脂肪酸酯(PHAs)是一类具有良好可降解性和生物相容性的高分子材料,其性能随分子结构变化可以大幅度调节,为高分子材料设计提供了新方法。从分子结构的设计角度简述了PHAs的微生物合成,从菌种、培养条件(主要是碳源等)、代谢控物和基因重组4个层次,展示了PHA分子结构的调控方法。
关键词(KeyWords)： 聚羟基脂肪酸酯;分子结构调控;材料设计
基金项目(Foundation):
作者(Author): 徐军,贺文楠,张增民,陈国强
参考文献(References)：
- 1 Byrom D. Microbial Synthesis of Polymers and Polymer Precursors.Hanser Munich: Mobley D P, 1994． 24
- 2 Peoples O P and Sinskey A J. Novel biodegradable microbial polymers. Netherlands: Kluwer Academic Publishers, 1990． 191
- 3 Steinbuchel A and Fuchtenbusch B. Trends Biol Tech, 1998, 16:419
- 4 Lee S Y. Biotech and Bioeng, 1996, 49: 1
- 5 An Y X, Deng L S, Xing P X, et al. Europ Polym J, 1997, 33(9) : 1 449
- 6 Porier Y, Nawrath C and Somerville C. Biotechnology, 1995, 13:142
- 7 Doi Y, Kitamura S and Abe H. Macromol, 1995, 23:4 822
- 8 Matsusaki H, Abe H and Doi Y. Biomacromolecules, 2000, 1: 17
- 9 Senior P J, Dawes E A. Biochem, 1971, 125: 55
- 10 Seki H, Karita M and Suzuki A J. Chem Eng Jpn, 1993, 27:423
- 11 Lemoigne M. Ann Inst Pasteur, 1997, 41: 148
- 12 Suzuki T, Yamane T and Shimizu S. Appl Microbiol Biotechnol,1986, 24: 370
- 13 Doudoroff M, Stanier R Y. Nature, 1959, 183: 1 440
- 14 Schlegel H G, Gottschalk G, Von Bartha R. Nature, 1961, 191:463
- 15 EP 69 465． 1982
- 16 Doi Y, Kitamura S, Abe H. Macromol, 1995, 28 (14) : 4 822
- 17 Anderson A J and Dawes E A. Microbiol, 1990, 54: 450
- 18 Abe H, Doi Y, Fukushima T and Eya H. Int J Biol Macromol.1994, 16 (3) : 115
- 19 贺文楠,张增民,陈国强.1999高分子学术论文报告会论文集,合肥:1999． 20
- 20 贺文楠,徐军,张增民.中国工程院化工、冶金与材料工程学部第二届学术会议论文集,北京:1999． 419
- 21 Tsuge T, Fukui T, Matsusaki H, et al. FEMS Microb Let,1999, 184: 193
- 22 Kichise T, Fukui T, Yoshida Y and Doi Y. Int J Biol Macromol,1999, 25: 69
- 23 Antonio R V, Steinbuchel A, Rehm B H A. FEMS Microb Lett,2000, 182: 111